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Side effects are extremely uncommon with BOTOX® as it has been used for other conditions for over 20 years. Rare side effects following the use of BOTOX® Cosmetic for frown lines are headache, temporary eyelid droop and flu-like syndrome (2.0%). If you are concerned about possible Botox side effects, please discuss your apprehension with the highly experienced Toronto, Ontario Botox expert, Dr. Lista.